Artichoke Spinach Grilled Cheese

Featured in: Home Table Recipes

This indulgent sandwich transforms the classic spinach-artichoke dip into a handheld delight. Creamy blends of mozzarella, Monterey Jack, and Parmesan marry with chopped artichoke hearts and fresh spinach between buttery sourdough slices. Grilled to golden perfection, each bite delivers crunch giving way to warm, gooey cheese filling. Ready in just 25 minutes, these sandwiches make satisfying vegetarian mains or hearty comfort food alongside warm tomato soup.

Updated on Wed, 21 Jan 2026 10:58:00 GMT
Golden-brown Artichoke Spinach Grilled Cheese sandwiches on sourdough, melted cheese peeking out from crispy edges.  Pin It
Golden-brown Artichoke Spinach Grilled Cheese sandwiches on sourdough, melted cheese peeking out from crispy edges. | casaflavors.com

The first time I made this, I was snowed in during a winter storm and desperate for something comforting. I had leftover spinach-artichoke dip from a party the night before and thought, why not put it between bread? The smell of garlic butter hitting the hot skillet filled my tiny apartment, and I knew I was onto something special. Now it is my go-to when I need serious comfort food without much effort.

My roommate walked in mid-way through cooking and immediately asked for seconds. We ended up making four more sandwiches that afternoon, eating them standing up in the kitchen while snow piled up outside the windows. Sometimes the best meals happen completely by accident.

Ingredients

  • Fresh spinach: Adds a mild earthiness that balances the rich dairy, plus wilts beautifully into the cheese mixture
  • Artichoke hearts: The heart of this recipe with their subtle tangy bite and tender texture
  • Cream cheese: Creates that velvety spreadable base that binds everything together
  • Mozzarella and Monterey Jack: The melting power duo that delivers maximum cheesiness
  • Parmesan: Brings a salty, nutty depth that keeps the filling from being too mild
  • Sourdough bread: Sturdy enough to hold the filling and develops the perfect crunch when buttered and grilled
  • Garlic and red pepper flakes: Small but mighty flavor boosters that wake up all that creamy richness

Instructions

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Mix the filling:
Combine all your cheeses, spinach, artichokes, garlic, and seasonings in a bowl until you have a spreadable, uniform mixture
Assemble the sandwiches:
Spread the cheesy filling generously onto four slices of sourdough, then top with the remaining slices to close them up
Butter the bread:
Spread softened butter on the outside of each sandwich so every bite gets that golden crispiness
Grill to perfection:
Cook in a hot skillet for 3 to 4 minutes per side, pressing gently, until the bread turns deep golden brown and you can see cheese starting to ooze out the edges
Rest and serve:
Let the sandwiches sit for a minute so the filling sets slightly, then slice diagonally and serve while still hot and gooey
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Transfer liquids, oils, and dry ingredients cleanly into bottles and jars while cooking or baking.
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Slices of Artichoke Spinach Grilled Cheese rest on a plate, served beside a warm bowl of tomato soup.  Pin It
Slices of Artichoke Spinach Grilled Cheese rest on a plate, served beside a warm bowl of tomato soup. | casaflavors.com

This recipe has gotten me through more bad days and lazy Sundays than I can count. There is something about the combination of warm, melty cheese and crisp bread that just fixes everything.

Making It Your Own

I have found that adding chopped sun-dried tomatoes or even a bit of crispy bacon takes these sandwiches over the top. The key is making sure any add-ins are well drained so they do not make the bread soggy during cooking.

The Perfect Sides

A simple tomato soup or mixed green salad balances all that richness beautifully. Sometimes I serve it with a light vinaigrette dressed salad, the acid cuts through the cheese and feels like a restaurant meal.

Meal Prep Magic

You can mix up the cheese filling two days ahead and keep it refrigerated. Having it ready to go means weeknight dinners become as easy as spreading, buttering, and grilling.

  • Let the chilled filling come to room temperature for 10 minutes before spreading
  • Resist overstuffing the sandwiches or the cheese will escape during cooking
  • A cast iron skillet gives the most even heat and best crunch
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A close-up of Artichoke Spinach Grilled Cheese, showing creamy spinach and artichoke filling melting between toasted sourdough. Pin It
A close-up of Artichoke Spinach Grilled Cheese, showing creamy spinach and artichoke filling melting between toasted sourdough. | casaflavors.com

Hope this brings you as much comfort on snowy days as it has brought me.

Recipe FAQs

Can I prepare the filling ahead of time?

Yes, mix the cheese and vegetable filling up to 2 days in advance. Store refrigerated in an airtight container, then assemble and grill when ready to serve.

What bread works best for these sandwiches?

Sourdough provides ideal texture and tangy flavor. Whole wheat adds fiber, while gluten-free bread accommodates dietary needs. Choose sturdy slices that hold the generous filling without getting soggy.

How do I prevent the bread from burning before cheese melts?

Cook over medium heat, not high. This allows bread to brown gradually while interior heats through enough to melt the cheese blend. Press gently but don't smash while grilling.

Can I add other vegetables to the filling?

Absolutely. Sun-dried tomatoes, chopped scallions, roasted red peppers, or sautéed mushrooms complement the spinach-artichoke base. Keep additions finely chopped to maintain spreadability.

What should I serve with these sandwiches?

A bowl of tomato soup creates classic comfort pairing. Fresh green salad with vinaigrette balances richness. Or serve alongside roasted vegetables for a complete vegetarian meal.

Can I make these in a panini press instead?

Yes, a panini press works beautifully. Cook 3-5 minutes until golden with distinctive grill marks. The press ensures even melting and creates that signature crisp exterior.

Artichoke Spinach Grilled Cheese

Crispy sourdough with melted cheesy spinach-artichoke filling

Prep Time
15 mins
Time to Cook
10 mins
Overall Time
25 mins
Created by Fiona Chambers


Skill Level Easy

Cuisine Type American

Makes 4 Portions

Dietary Details Vegetarian

What You'll Need

Vegetables

01 1 cup fresh spinach, chopped (or ½ cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 ½ cup shredded mozzarella cheese
03 ½ cup shredded Monterey Jack or Swiss cheese
04 ¼ cup grated Parmesan cheese
05 2 tbsp unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 ¼ tsp black pepper
03 ⅛ tsp crushed red pepper flakes (optional)
04 Pinch of salt

How to Make It

Step 01

Prepare the Spinach-Artichoke Filling: In a mixing bowl, combine cream cheese, mozzarella, Monterey Jack (or Swiss), Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and a pinch of salt. Mix until well blended.

Step 02

Assemble the Sandwiches: Lay out the sourdough slices. Spread the artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form sandwiches.

Step 03

Butter the Bread: Lightly butter the outside of each sandwich on both sides.

Step 04

Grill the Sandwiches: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3-4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and Serve: Remove from skillet, let rest 1 minute, then slice and serve warm.

Equipment Needed

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Info

Be sure to look over every ingredient for allergens, and talk to a health expert with any concerns.
  • Contains: Dairy (cheese, butter), Wheat (bread). May contain: Soy (depending on bread/cheese brands). Check labels for potential cross-contamination if allergies are severe.

Nutrition per Serving

Nutritional info is for general reference and isn't medical guidance.
  • Caloric Value: 410
  • Fats: 23 g
  • Carbohydrates: 38 g
  • Proteins: 15 g